My wife's computer is now running Ubuntu Linux 8.04 (hardy heron). She no longer has any dependency on Microsoft software. I didn't think it was possible, but I might have fallen just a little bit more in love with her.
Actually, the sad truth is that for now I'm the one that still has a couple of Windows dependencies. (Those would be easily remedied by a conversion to Apple products, but that's never struck me as worthwhile maneuver.) I maintain a personal wiki page that tracks the pieces of software I need to be available (and not awful) on Linux before my dependency is broken, and over the years progress has been steadily made in that space. So, if you're a FOSS junky and you work on multi-track audio software, multi-track video editing software, DVD authoring software, or a good Microsoft Money/Quicken clone, you have my undivided attention!